Name: Adintrevimab
Brand: TargetMol
SKU: T76900
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 2,490

2-4周

5 mg

¥ 6,470

2-4周

10 mg

¥ 9,870

2-4周

生物活性

产品描述	Adintrevimab (ADG20) is a broad-spectrum neutralizing monoclonal antibody targeting SARS-CoV-2. It binds to a highly conserved epitope within the receptor-binding domain (RBD) of the spike glycoprotein, blocking its interaction with the ACE2 receptor. The Fc region is modified to extend its in vivo half-life. Research demonstrates potent neutralizing activity against various variants including Alpha, Beta, Gamma, and Delta, although its activity is significantly reduced against certain Omicron sub-lineages.
体外活性	在体外实验中，Adintrevimab 通过结合保守的 RBD 表位，对 SARS-CoV-2 变体（Alpha 至 Delta）表现出强效中和作用，但对 Omicron BA.1 的活性降低，且对 BA.2-BA.5 亚系缺乏活性 [1]。
体内活性	在感染 SARS-CoV-2/WA1/2020 的叙利亚黄金仓鼠（5-6 周龄雌性）预防性给药研究中，通过腹腔单次注射 Adintrevimab（9.25 至 2,000 μg，约 0.1 至 20 mg/kg）提供了剂量依赖性保护，有效降低了肺部病毒载量并显著减轻了病毒诱导的肺组织病理损伤 [1]。
别名	艾定韦单抗, ADG 20
反应种属	Virus
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P0DTC2
靶点	SARS-CoV-2

化学信息

CAS No.

2516243-54-0

储存&溶解度

存储

Adintrevimab