Name: A 68930 hydrochloride
Brand: TargetMol
SKU: T21680
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

¥ 4,970

35日内发货

生物活性

产品描述	A 68930 hydrochloride is a selective dopamine D1 receptor agonist that ameliorates Aβ1–42-induced cognitive impairment and neuroinflammation in mouse models, highlighting its relevance to Alzheimer’s disease research, and at concentrations of 10–50 μg/mL also inhibits gastric H⁺/K⁺-ATPase activity comparably to omeprazole, supporting multifunctional pharmacological investigations.
体外活性	The dopamine D1 receptor protein was detected in native human airway epithelium and three sources of cultured human airway epithelial cells. A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein [1]. A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression [1]. A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels [1]. Western Blot Analysis [1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR [1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence [1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.
别名	A68930 hydrochloride, 68930 盐酸盐

化学信息

分子量	307.77
分子式	C₁₆H₁₈ClNO₃
CAS No.	130465-39-3
Smiles	C(N)[C@H]1C=2C(C[C@H](O1)C3=CC=CC=C3)=C(O)C(O)=CC2.Cl
密度	no data available

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (259.93 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2492 mL	16.2459 mL	32.4918 mL	162.4590 mL
5 mM	0.6498 mL	3.2492 mL	6.4984 mL	32.4918 mL
10 mM	0.3249 mL	1.6246 mL	3.2492 mL	16.2459 mL
20 mM	0.1625 mL	0.8123 mL	1.6246 mL	8.1229 mL
50 mM	0.0650 mL	0.3249 mL	0.6498 mL	3.2492 mL
100 mM	0.0325 mL	0.1625 mL	0.3249 mL	1.6246 mL