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Theaflavin

Theaflavin

产品编号 T7602   CAS 4670-05-7

Theaflavin 是在红茶中发现的一种多酚类黄酮,具有如抗氧化、抗癌、抗炎和抗病毒多种生物活性。

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Theaflavin Chemical Structure
Theaflavin, CAS 4670-05-7
规格 价格/CNY 货期 数量
1 mg ¥ 283 现货
5 mg ¥ 648 现货
10 mg ¥ 950 现货
25 mg ¥ 1,450 现货
50 mg ¥ 2,150 现货
100 mg ¥ 3,180 现货
1 mL * 10 mM (in DMSO) ¥ 980 现货
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
MG-132限时半价
重组蛋白限时优惠
产品目录号及名称: Theaflavin (T7602)
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纯度: 98%
纯度: 95.77%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
植物来源
结构类型
产品描述 Theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antioxidant, anticancer, anti-inflammatory, and antiviral properties
体外活性 Theaflavin inhibits the growth of OVCAR-3 and A2780/CP70 human ovarian cancer cell lines, but not the ovarian epithelial cell line IOSE 364 (IC50s = 11.9, 38.5, and >40 μM, respectively)[1].
体内活性 In the pretreated ICH rats TF significantly alleviated the behavioral defects, protected BBB integrity, and decreased the formation of cerebral edema and the levels of ROS as well as inflammatory cytokines (including interleukin-1 beta [IL-1β], IL-18, tumor nectosis factor-alpha, interferon-γ, transforming growth factor beta, and (C-X-C motif) ligand 1 [CXCL1]).?Nissl staining and TUNEL displayed TF could protect against the neuron loss and apoptosis via inhibiting the activation of nuclear transcription factor kappa-β-p65 (NF-κβ-p65), caspase-1, and IL-1β[2].
细胞实验 Cell proliferation assay, Hoechst 33342 staining assay, Caspase-Glo Assay, western blot, human umbilical vein endothelial cell tube formation assay and vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay were performed[1].
动物实验 ICH rat models were induced with type VII collagenase and pretreated with TF by gavage in different doses (25 mg/kg-100 mg/kg).?Twenty-four hours after ICH attack, evaluated the rats' behavioral performance, the blood-brain barrier (BBB) integrity, and the formation of cerebral edema.?The levels of reactive oxygen species (ROS) and inflammatory cytokines were examined by 2',7'-dichlorofluorescin diacetate and enzyme-linked immunosorbent assay.?Nissl staining and transferase dUTP nick end labeling (TUNEL) were aimed to detect the neuron loss and apoptosis, the mechanism of which was explored by Western blot[2].
分子量 564.49
分子式 C29H24O12
CAS No. 4670-05-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 5.65 mg/mL (10 mM), Sonification is recommended

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7715 mL 8.8576 mL 17.7151 mL 44.2878 mL
5 mM 0.3543 mL 1.7715 mL 3.543 mL 8.8576 mL
10 mM 0.1772 mL 0.8858 mL 1.7715 mL 4.4288 mL

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TargetMol Library Books参考文献

1. Gao Y , Rankin G O , Youying T U , et al. Inhibitory Effects of the Four Main Theaflavin Derivatives Found in Black Tea on Ovarian Cancer Cells[J]. Anticancer research, 2016, 36(2):643-651. 2. Guanglei F , Hua W , Youli C , et al. Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats[J]. Drug Design, Development and Therapy, 2018, Volume 12:1609-1619. 3. Juarez-Mercado K E, Prieto-Martinez F D, Sanchez-Cruz N, et al. DNA Methyltransferase Inhibitors with Novel Chemical Scaffolds[J]. bioRxiv. 2020 4. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors[J]. Pharmaceuticals. 2021, 14(1): 17.

TargetMol Library Books文献引用

1. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors. Pharmaceuticals. 2021, 14(1): 17. 2. Yang X, Liu L, Hao Y, et al. A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro. Viruses. 2021, 13(6): 1055.
Tubercidin U0126-EtOH Ginsenoside Rb2 Isoferulic acid AG-1478 Shegansu B Loxoribine Dihydromyricetin

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 免疫/炎症分子化合物库 抗氧化化合物库 抗病毒中药单体化合物库 铁死亡化合物库 中药单体化合物库 抗癌化合物库 抗癌天然产物库 抗病毒库 中药抗炎分子库

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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

Theaflavin 4670-05-7 Metabolism Microbiology/Virology Influenza Virus Endogenous Metabolite inhibit Inhibitor inhibitor

 

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