Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 142 | 现货 | ||
5 mg | ¥ 287 | 现货 | ||
10 mg | ¥ 429 | 现货 | ||
25 mg | ¥ 735 | 现货 | ||
50 mg | ¥ 1,090 | 现货 | ||
100 mg | ¥ 1,650 | 现货 | ||
200 mg | ¥ 2,470 | 现货 | ||
500 mg | ¥ 4,180 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 387 | 现货 |
产品描述 | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. |
靶点活性 | Leishmania infantum:2.5 μM |
体外活性 | Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3]. |
体内活性 | Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3]. |
别名 | 喷他脒二盐酸盐, MP-601205 dihydrochloride |
分子量 | 413.34 |
分子式 | C19H26Cl2N4O2 |
CAS No. | 50357-45-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/ml (87.10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4193 mL | 12.0966 mL | 24.1932 mL | 60.4829 mL |
5 mM | 0.4839 mL | 2.4193 mL | 4.8386 mL | 12.0966 mL | |
10 mM | 0.2419 mL | 1.2097 mL | 2.4193 mL | 6.0483 mL | |
20 mM | 0.121 mL | 0.6048 mL | 1.2097 mL | 3.0241 mL | |
50 mM | 0.0484 mL | 0.2419 mL | 0.4839 mL | 1.2097 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pentamidine dihydrochloride 50357-45-4 Metabolism Microbiology/Virology Phosphatase Antibacterial Antibiotic Parasite Antifungal PTP1B Pneumocystis Pentamidine MP601205 antitumor Inhibitor Kidney carinii Bacterial cell-cycle 喷他脒二盐酸盐 pneumonia inhibit MP 601205 MP-601205 DNA MP 601205 Dihydrochloride MP601205 Dihydrochloride Pentamidine Dihydrochloride biosynthetics MP-601205 Dihydrochloride Fungal arrest MP-601205 dihydrochloride inhibitor