2-tert-Butyl-1,4-benzoquinone

Name: 2-tert-Butyl-1,4-benzoquinone
Brand: TargetMol
SKU: TN6750
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.19%

货号 TN6750Cas号 3602-55-9

别名 叔丁基对苯醌

2-tert-Butyl-1,4-benzoquinone 是丁基化羟基茴香醚 (BHA) 的亲电子代谢物，它在 RAW264.7 细胞中引起 Nrf2 的活化及其负调节剂 Keap1 的 S-芳基化。

2-tert-Butyl-1,4-benzoquinone

一键复制产品信息

很棒

纯度: 97.19%

货号 TN6750 别名 叔丁基对苯醌Cas号 3602-55-9

2-tert-Butyl-1,4-benzoquinone 是丁基化羟基茴香醚 (BHA) 的亲电子代谢物，它在 RAW264.7 细胞中引起 Nrf2 的活化及其负调节剂 Keap1 的 S-芳基化。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 165	现货

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产品介绍

2-tert-Butyl-1,4-benzoquinone AI Summary

2-tert-Butyl-1,4-benzoquinone exhibits a range of bioactivities including antifeedant, termiticidal, cytotoxic, antibacterial, antifungal, antioxidant, and enzyme inhibitory properties. It reduces the consumption of filter paper by Coptotermes formosanus and demonstrates varying termite mortality rates post-exposure, indicating insecticidal potential. The compound activates Nrf2 in human HepG2-ARE-C8 cells with dose-dependent ARE upregulation, showing fold changes from 1.18 to 8.46. It exhibits cytotoxicity against various human cell lines with IC50 values ranging from 15540.0 nM to 56830.0 nM and demonstrates antibacterial and antifungal activities with MIC values between 237510.0 nM to 475030.0 nM and 121800.0 nM respectively. An LC50 of 27.4 ppm is observed in Brine shrimp toxicity tests. 2-tert-Butyl-1,4-benzoquinone induces apoptosis in NCI-H460 and HaCaT cells and acts as a superoxide anion radical scavenger. It inhibits growth in human A2780, OVCAR8, A2780cis, and SV-40 immortalized human ovarian epithelial cells with IC50 values in the low micromolar range, and shows antiplasmodial activity against Plasmodium falciparum Dd2 with an IC50 of 15600.0 nM. As an inhibitor of Schistosoma mansoni DHODH, it exhibits 20.6% inhibitory activity at 500 uM and an IC50 of 768,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.
别名	叔丁基对苯醌

化学信息

分子量	164.2
分子式	C₁₀H₁₂O₂
CAS No.	3602-55-9
Smiles	CC(C)(C)C1=CC(=O)C=CC1=O
密度	1.092 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (365.41 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0901 mL	30.4507 mL	60.9013 mL	304.5067 mL
5 mM	1.2180 mL	6.0901 mL	12.1803 mL	60.9013 mL
10 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
20 mM	0.3045 mL	1.5225 mL	3.0451 mL	15.2253 mL
50 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0901 mL
100 mM	0.0609 mL	0.3045 mL	0.6090 mL	3.0451 mL