2deoxydglucose

2-Deoxy-D-glucose (2-DG) 是葡萄糖的类似物，是一种糖酵解抑制剂。2-Deoxy-D-glucose 具有抗病毒活性，还具有抑制细胞增殖、诱导细胞凋亡的活性。

2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg ml.4,5In vivo, 2-deoxy-D-glucose (500 mg kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin or paclitaxel .6 1.Kang, H.T., and Hwang, E.S.2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimeticLife Sci.78(12)1392-1399(2006) 2.Aft, R.L., Zhang, F.W., and Gius, D.Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell deathBr. J. Cancer87(7)805-812(2002) 3.Ralser, M., Wamelink, M.M., Struys, E.A., et al.A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growthProc. Natl. Acad. Sci. USA105(46)17807-17811(2008) 4.Liu, H., Savaraj, N., Priebe, W., et al.Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: A strategy for solid tumor therapy (Model C)Biochem. Pharmacol.64(12)1745-1751(2002) 5.Zhang, X.D., Deslandes, E., Villedieu, M., et al.Effect of 2-deoxy-D-glucose on various malignant cell lines in vitroAnticancer Res.26(5A)3561-3566(2006) 6.Maschek, G., Savaraj, N., Priebe, W., et al.2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivoCancer Res.64(1)31-34(2004)

2-Deoxy-D-glucose 6-phosphate disodium 是一种葡萄糖类似物，可抑制糖酵解，抑制己糖激酶和葡萄糖-6-磷酸异构酶的功能。

2-Azido-2-deoxy-D-glucose(2-ADG)作为一种糖基化抑制剂,主要应用于探索糖基化酶的作用机制.

2-[(Azidoacetyl)amino]-2-deoxy-D-glucose, 98% 在糖生物学研究中具有应用潜力。

2-Azido-2-deoxy-D-glucose tetraacetate 在糖生物学研究中具有应用潜力。

2-Deoxy-D-glucose-tetraacetate 是用于糖生物学研究的生化试剂。糖生物学研究包括糖的结构、合成、生物学与进化，涉及碳水化合物化学、聚糖的形成与降解酶学、蛋白质-聚糖识别及聚糖在生物系统中的作用。这个领域紧密连结基础研究、生物医学和生物技术。