α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC50 value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research [1].

α1A-adrenoceptor:2.86 μM (DC50)

α1A-AR Degrader 9c（化合物9c）（50 mg/kg，IP，每日一次，连续15天）显著抑制了肿瘤生长[1]。