tag-7

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.

Thalidomide-4-Br,7-F 是一种 E3 连接酶活化剂，包含一个溴和一个氟。E3 连接酶作为一种蛋白质，可以通过泛素化过程标记其他蛋白质，从而导致其降解。该化合物上的两个卤素都可被替代，以实现进一步的衍生化。

LL-K9-3是一种基于选择性疏水标记技术（HyT）的CDK9-cyclin T1复合物降解剂（DC50值分别为cyclin T1的589 nM和CDK9的662 nM）。它由CDK9抑制剂SNS 032和一个糖基连接器连接到疏水标记组成。LL-K9-3不会降解其他CDKs（CDK1、2、4、5、6和7）。在22RV1细胞中，LL-K9-3通过诱导CDK9和cyclin T1的选择性和同步降解，降低雄激素受体（AR）和cMyc的表达。

Palmitoleic acid alkyne, an ω-terminal alkyne derivative of palmitoleic acid, facilitates click chemistry applications. This compound has played a crucial role in examining protein palmitoylation processes. Specifically, the cis form of palmitoleic acid alkyne selectively tags wild-type Wnt3a protein within mouse fibroblast L-cells expressing Wnt3a and its secretion in conditioned media, distinguishing itself from the trans form and proving ineffective against the S209A mutant Wnt3a.

T7 Tag Peptide 是一个由T7噬菌体编码的蛋白p10前导序列的11个氨基酸标记蛋白，可以被T7 tag标签抗体特异性识别，可用于不同的免疫检测以及亲和纯化。