r 411

Valategrast is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, with the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

Valategrast hydrochloride (R411) 是一种有效的整联蛋白 α4β1 (VLA-4) 和 α4β7 双重拮抗剂。Valategrast hydrochloride 可用于慢性阻塞性肺疾病 (COPD) 和哮喘的研究。

OICR41114 (PROTAC4) 是一种针对WDR5的PROTAC降解剂。其能够降解内源性WDR5，EC50为40 nM，Dmax为49%。OICR41114 通过蛋白酶体依赖性机制降解HiBiT标记的WDR5。OICR41114由靶蛋白配体Dimethyl-F-OICR-9429-COOH、E3连接酶配体OICR-8268-acrylic acid和PROTAC linker Amino-PEG9-amine组成。其中，E3连接酶配体与linker形成的偶联物为OICR-8268-acrylic acid-amino-PEG9-amine。

SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research.