Name: SSR411298
Brand: TargetMol
SKU: T40775
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

2 mg

¥ 3,490

5日内发货

生物活性

产品描述	SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research.
体外活性	SSR411298 (0.1, 1, 10, 100, 1000, 10000 nM) inhibits mouse brain FAAH in a concentration-dependent manner[1]. SSR411298 produces maximal inhibition of FAAH between 0.3 and 30 mg/kg in the ex-vivo experiment[1].
体内活性	SSR411298 (0.3, 1, 3 mg/kg; p.o.; twice a day during 2 days; 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing) produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress model, restoring notably the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g[1]. SSR411298 (0.3, 1, 3, 10 mg/kg; po; single dose; two hours prior to sacrifice) produces a significant global increase of tissular AEA, PEA and OEA levels in the hippocampus, but not of 2-AG levels[1].
别名	SSR411298

化学信息

分子量	402.447
分子式	C₂₁H₂₆N₂O₆
CAS No.	666860-59-9
Smiles	COc1ccc2c(cccc2c1)[C@H]1CO[C@H](CCCNC(=O)OCC(N)=O)OC1 \|wU:15.17,wD:12.13,(-17.34,8.47,;-17.34,6.93,;-16,6.16,;-14.67,6.93,;-13.34,6.16,;-13.34,4.62,;-12,3.85,;-12,2.31,;-13.34,1.54,;-14.67,2.31,;-14.67,3.85,;-16,4.62,;-10.67,4.62,;-9.34,3.85,;-8,4.62,;-8,6.16,;-6.67,6.93,;-5.33,6.16,;-4,6.93,;-2.67,6.16,;-1.33,6.93,;-1.33,8.47,;,6.16,;1.33,6.93,;2.67,6.16,;4,6.93,;2.67,4.62,;-9.34,6.93,;-10.67,6.16,)\|

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

SSR411298