quinaprilat

Quinaprilat inhibits angiotensin converting enzyme.

Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme inhibitor used in the treatment of congestive heart failure and hypertension.

Quinaprilat hydrochloride 是一种口服活性的非巯基血管紧张素转换酶 (ACE) 抑制剂，且为 Quinapril 的活性代谢物。该化合物特异性抑制血管紧张素 I 向血管收缩剂血管紧张素 II 的转化，并抑制缓激肽的降解，具有抗高血压剂和血管扩张剂的作用。

Quinapril是一种可口服的非肽和非巯基血管紧张素转换酶（ACE）抑制剂。它专门阻止血浆与组织中的血管紧张素I向血管紧张素II的转换。Quinapril通过酶水解生成具有药理活性的Quinaprilat，对高血压模型具有疗效。

Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.