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Search Results for " psoriasis-associated "

Targets Recommended: Antibacterial Antibiotic

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0500	Chloroxine Capitrol,氯喔星	Antibacterial; Antibiotic	Microbiology/Virology
	Chloroxine (Capitrol) 是重要的 8-羟基喹啉衍生物之一，有抗细菌，抗真菌，抗原生动物和抗阿米巴虫活性，可研究肠道阿米巴病，还可研究头皮屑和头皮脂溢性皮炎。
T76884	Spesolimab BI 655130	IL Receptor	Immunology/Inflammation
	Spesolimab (BI 655130) 是一种抗白细胞介素-36 受体抗体。IL-36 在免疫系统中具有重要作用，与先天性 Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。Spesolimab 可用于研究全身性脓疱型银屑病、掌跖脓疱病 (PPP) 和特应性皮炎。。
T77677	12R-LOX-IN-2	Lipoxygenase	Metabolism
	12R-LOX-IN-2 是一种 12R-脂氧合酶 (12R-LOX) 的抑制剂。12R-LOX-IN-2 抑制咪喹莫特 (IMQ) 诱导银屑病角质形成细胞过度增殖，并抑制细胞集落形成。12R-LOX-IN-2 还降低 IMQ 诱导细胞中 Ki67 的蛋白水平和 IL-17A 的 mRNA 表达。12R-LOX-IN-2 可用于牛皮癣和其他皮肤相关炎症性疾病的研究。
T81261	ROCK2-IN-7	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-7是针对ROCK2的激酶抑制剂，能够抑制ROCK2/pSTAT3信号通路。该化合物在治疗银屑病模型中有着明显效果，通过抑制全身免疫激活，从而减轻炎症。
T78298	Alefacept LFA 3TIP,Human LFA 3IgG fusion protein,BG 9273
	Alefacept (BG 9273)为一种人类淋巴细胞功能相关抗原3/免疫球蛋白1融合蛋白，主要在慢性斑块状银屑病研究中使用。
T40043	RORγt Inverse agonist 10
	RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits the activity of RORγt, a prominent transcription factor involved in the regulation of genes associated with the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R.

化合物

Chloroxine

Cat.No: T0500

Synonym: Capitrol,氯喔星

Target: Antibacterial, Antibiotic

Spesolimab

Cat.No: T76884

Synonym: BI 655130

Target: IL Receptor

12R-LOX-IN-2

Cat.No: T77677

Synonym:

Target: Lipoxygenase

Synonym: LFA 3TIP,Human LFA 3IgG fusion protein,BG 9273

Target:

RORγt Inverse agonist 10

Cat.No: T40043

Synonym:

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02174	FABP5 Protein, Human, Recombinant PA-FABP,E-FABP,fatty acid binding protein 5 (psoriasis	Human	E. coli
	Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein which Belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid-binding proteins ( FABPs ) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. E-FABP / FABP5 is pre...
TMPJ-01073	FABP5 Protein, Human, Recombinant (His) Fatty Acid-Binding Protein Epidermal,PA-FABP,FABP5,Psori...	Human	E. coli
	Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP5 can be expressed in keratinocytes, and is highly expressed in psoriatic skin. FABP5 has been shown to be involved in keratinocyte differentiation. FABP5 has high specificity for fatty acids, the highest affinity for C18 chain...
TMPY-02153	TNF beta Protein, Human, Recombinant LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPK-00668	IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) NILR,IL-21 receptor,IL-21R,CD360	Cynomolgus	HEK293 Cells
	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker i...
TMPJ-00351	IL-23R Protein, Human, Recombinant (aa 24-353, hFc) IL-23 receptor,IL23R,Interleukin-23 receptor,IL-23R	Human	HEK293 Cells
	Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the I...
TMPJ-01219	IL-23R Protein, Mouse, Recombinant (hFc) Il23r,IL-23R,interleukin 23 receptor,Interleukin-23 receptor...	Mouse	HEK293 Cells
	Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, an...