protac mdm2 degrader-2

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].

MI-1063 是一种DMD-2抑制剂，能够阻断MDM2与p53的相互作用，从而激活p53的肿瘤抑制功能。MI-1063 对RS4-11和MV4-11癌细胞的生长有抑制效果，其IC50值分别为179 nM和93 nM。MI-1063 还可作为靶蛋白配体用于合成PROTAC降解剂MD-265。

MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].