p-64

CP-642931 (Sorbitol dehydrogenase-IN-1) 是一种具有口服活性和高效性的山梨醇脱氢酶 sorbitol dehydrogenase 抑制剂，可用于研究糖尿病和心血管疾病。

CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂，抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。

CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶（ACC）抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。

CP-64434 hydrate is an antibiotic; anti-proliferative HDAC inhibitor.

RP-64477 是有效的胆固醇酯化酶酰基辅酶 A：胆固醇 O-酰基转移酶 (ACAT) 抑制剂。

MJP6412 作为一种高效的 p300 CBP 降解剂，具有极低的 DC50 值，分别对 p300 和 CBP 为1.6 nM 和 1.2 nM。因其显著效力，MJP6412 在癌症研究领域中扮演关键角色。

CGP64222, a peptoid Tat transactivation response element inhibitor, inhibits human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.

FPL-64170XX is a selective inhibitor of the enzyme 5-lipoxygenase.

UBP646 is a GluN1/GluN2 receptors potentiator.

Anti-AcmNPV Envelope glycoprotein gp64 AcmNPV-gp64 Antibody (9B642) 是一种靶向AcMNPV AcmNPV Envelope glycoprotein gp64 AcmNPV-gp64 的单克隆抗体，是一种 Mouse IgG1 抗体。

(Trp63,Trp64)-C3a(63-77) 是一种合成的 C3a 类似肽，在人中性粒细胞和表达 hC3aR 或 mC3aR 的 RBL-2H3 细胞中刺激 Ca2+通量，EC50 分别为 9.5、2.0 和 0.8 nM。

ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.

CGP 64213 is a GABAb receptor agonist.

Risperidone (R 64 766) 是5-HT2受体阻断剂、P-糖蛋白抑制剂和多巴胺 D2受体的拮抗剂，对 5-HT2A 和多巴胺 D2受体的 Ki 值分别为 4.8 和 5.9 nM。

Antibacterial agent 128 是一种带有可裂解接头的铁载体类似物-环丙沙星 (Ciprofloxacin (Ciprofloxacin )) 偶联物。Antibacterial agent 128 显示出针对铜绿假单胞菌 (MIC 值为 0.25-64 μg mL) 和类鼻疽伯克氏菌 (MIC 值为 1-32 μg mL) 的抗生素活性。

Cys-pexiganan是一种抗微生物肽，是pexiganan的衍生物，具有N-末端的半胱氨酸。它对P. aeruginosa和S. aureus具有活性（MICs分别为64和16 µg/ml）。Cys-pexiganan与含醋酸纤维素的聚乙烯醇电纺垫结合，可以加速隔离的重钙化人类血浆的凝血。

LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activity against various strains including E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883, and P. aeruginosa 5567. The minimum inhibitory concentration (MIC) values for these strains are 16 μg/mL, 4 μg/mL, 64 μg/mL, and 4 μg/mL, respectively.

Risperidone hydrochloride (R 64 766 hydrochloride) 是一种 5-HT2 受体的阻断剂，P-糖蛋白 (P-Glycoprotein) 的抑制剂和 dopamine D2 受体的拮抗剂，其能够作用于 5-HT2A (Ki: 4.8 nM) 和 dopamine D2 (Ki: 5.9 nM)受体。

ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). 1.Calzaferri, F., Narros-Fernández, P., de Pascual, R., et al.Synthesis and pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammationJ. Med. Chem.64(4)2272-2290(2021)

Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM, respectively, in CHO cells expressing the human transporters.3

BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽，由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时，对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应，并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内，BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。

HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。

Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across isolated goby posterior intestine in 5% seawater-adapted solution.3In vivo, urotensin II (1.5-150 nmol/kg) decreases diastolic blood pressure and increases heart rate in anesthetized rats.4It also reduces the pressor responses to sympathetic nerve stimulation, norepinephrine , and vasopressin in pithed rats when administered at a dose of 150 nmol/kg. 1.Ames, R.S., Sarau, H.M., Chambers, J.K., et al.Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14Nature401(6750)282-286(1999) 2.Loretz, C.A., and Assad, J.A.Urotensin II lowers cytoplasmic free calcium concentration in goby enterocytes: Measurements using quin2Gen. Comp. Endocrinol.64(3)355-361(1986) 3.Loretz, C.A., Freel, R.W., and Bern, H.A.Specificity of response of intestinal ion transport systems to a pair of natural peptide hormone analogs: Somatostatin and urotensin IIGen. Comp. Endocrinol.52(2)198-206(1983) 4.Gibson, A., Wallace, P., and Bern, H.A.Cardiovascular effects of urotensin II in anesthetized and pithed ratsGen. Comp. Endocrinol.64(3)435-439(1986)

Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.