Cys-pexiganan, a derivative of pexiganan with an added N-terminal cysteine, is an antimicrobial peptide effective against P. aeruginosa and S. aureus, with minimum inhibitory concentrations (MICs) of 64 and 16 µg/ml, respectively. Its conjugation to cellulose acetate-incorporated polyvinyl alcohol electrospun mats enhances the clotting of isolated recalcified human plasma.