men 1

Men 10376 TFA 是一种有效的选择性的 tachykinin NK-2受体拮抗剂，对大鼠小肠 NK-2 受体的Ki 值为 4.4 μM。

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Men 10208 is an antagonist of the neurokinin A receptor.

MEN 10207 is an antagonist of tachykinin.

Men 10456 is a MEN 10376 derivative.

Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5).

Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) 是一种有效的选择性速激肽 nk-2 受体拮抗剂，对大鼠小肠 nk-2 受体的 K I 值为 4.4 M。

MEN 10207 acetate 是 NK-2 速激肽受体的选择性拮抗剂。

MEN11467 是一种可口服的新型有效且具有选择性的拟肽速激肽 NK 1 受体拮抗剂，可用于研究急性结肠癌。

TX-1123是一种针对Src、eEF2-K、PKA和EGFR-K PKC的有效蛋白酪氨酸激酶(PTK)抑制剂，同时也是一种环氧合酶(COX)抑制剂，对COX2和COX1的IC50值分别为1.16μM和15.7μM。它具有低线粒体毒性，可用于癌症研究。

MEN-10612 is a cyclic pseudopeptide and potent tachykinin NK-2 receptor antagonist.

Sabarubicin 是一种阿霉素双糖类似物，具有显著的抗肿瘤活性。Sabarubicin 作为一种拓扑异构酶 II 毒药比阿霉素更有效，并在较低的细胞内浓度下刺激 DNA 片段。

MEN-10627 is a polycyclic peptide and tachykinin NK2 receptor antagonist.

WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

MEN-10573 is a cyclic pseudopeptide and potent tachykinin NK-2 receptor antagonist.

Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; binding of this agent to PRs inhibits PR activation and the associated proliferative effects. Unlike many other antiprogestins such as mifepristone, this agent does not appear to convert to an agonist in the presence of protein kinase A (PKA) activators and shows high antiprogestagenic activity on both progesterone receptor (PR) isoforms PR-A and PR-B.

UNC1666 is a dual ATP-competitive small molecule tyrosine kinase inhibitor, which potently diminishes Mer and Flt3 phosphorylation in AML.

MEN-10354 is a less potent and less selective NK-2 tachykinin receptor antagonist compared to the linear analog, R 396.