mdk

iMDK 是PI3K 抑制剂，能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌，而不会伤害正常细胞和小鼠。

MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.

MDK6204 is a selective inhibitor of CLK1 and CLK2.

MDK-4683, also known as CA IX XII Inhibitor, is a hCA IX and hCA XII inhibitor.

MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in obesity.

MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.

MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.

MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).

MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).

MDK-3345 is a reversible covalent inhibitor for Mcl-1.

MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively.

MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation

MDK49781 is a useful chemical intermediate for drug synthesis.

MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.

MDK8228 is an inhibitor of CBP p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.

MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer.

MDK3673, also known as Olfr895-Agonist-10, is a novel specific agonist of odorant receptor 895 (Olfr895).

MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name.

MDK80908, also known as PPARalpha gamma agonist N15, is a dual PPARα γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8.

MDK03855, also known as A2AR antagonist 19, is an adenosine A2A receptor (A2AR) antagonist. MDK03855 has CAS#1454903-85-5. The last five digit of CAS# was used for name.

(S,R,S)-AHPC (VH032-NH2) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂，IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能，可用于癌症研究。

MDK-6983 (MDK-6983) 是一种自噬抑制剂，可破坏人黑色素瘤细胞中肌动蛋白细胞骨架的动力学。

MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂，可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。