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Anti-EphB3 Antibody-APC (8R580)

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产品编号 TMAY-03361A

Anti-EphB3 Antibody-APC (8R580) 是一种 APC-conjugated Rabbit 抗体,靶向 EphB3。Anti-EphB3 Antibody-APC (8R580) 可用于 FCM。

Anti-EphB3 Antibody-APC (8R580)

Anti-EphB3 Antibody-APC (8R580)

Rating icon 还可以
产品编号 TMAY-03361A

Anti-EphB3 Antibody-APC (8R580) 是一种 APC-conjugated Rabbit 抗体,靶向 EphB3。Anti-EphB3 Antibody-APC (8R580) 可用于 FCM。

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产品介绍

生物活性
产品描述
Anti-EphB3 Antibody-APC (8R580) is a APC-conjugated Rabbit antibody targeting EphB3. Anti-EphB3 Antibody-APC (8R580) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
克隆号
8R580
交叉反应
Mouse
验证活性
Flow cytometric analysis of Mouse EphB3 expression on CoLo205 cells. Cells were stained with APC-conjugated anti-Mouse Mouse EphB3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
10 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphB3 / HEK2 (rM EphB3 / HEK2; TMPY-01784; NP_034273.1; Met1-Thr537) and conjugated with APC under optimum conditions, the unreacted APC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.09% sodium azide
研究背景Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
偶联与修饰
偶联
APC
其他可选修饰符
Unconjugated/PE
可提供抗体种类
3
抗原信息
免疫原
Recombinant Mouse EphB3 / HEK2 protein (TMPY-01784)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
运输方式Shipping with blue ice.

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