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TargetMol产品目录中 "

ldl-in-3

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  • 抑制剂&激动剂
    12
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    4
    TargetMol | Recombinant_Protein
  • 天然产物
    4
    TargetMol | Natural_Products
  • 同位素
    1
    TargetMol | Isotope_Products
  • LDL-IN-3
    T10063180908-67-2In house
    LDL-IN-3 具有抗动脉粥样硬化和抗氧化活性。
    • ¥ 3730
    现货
    规格
    数量
    TargetMol | Inhibitor Hot
  • Isorhamnetin
    3-methylquercetin, 3'-Methylquercetin, Isorhamnetol, 异鼠李素, 3'-Methoxyquercetin
    T2836480-19-3
    Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮,可通过抑制MEK1和PI3K 来抑制皮肤癌。
    • ¥ 263
    现货
    规格
    数量
    TargetMol | Citations 客户已引用
  • PCSK9 modulator-3
    T606462476490-18-1
    PCSK9 modulator-3 (Compound 13) 是PCSK9的有效调节剂,EC50值为 2.46 nM,在高脂血症研究中具有潜力。PCSK9 是已证实的降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。
    • ¥ 10600
    6-8周
    规格
    数量
  • 9(S)-HODE
    T3672773543-67-6
    9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.[1],[2] It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles.[3]
    • ¥ 10600
    6-8周
    规格
    数量
  • Tiliroside
    银椴苷;椴树苷, 银椴甙, Tribuloside
    T5S117220316-62-5
    Tiliroside (Tribuloside) 是糖苷类黄酮,是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收,具有抗糖尿病作用。
    • ¥ 233
    现货
    规格
    数量
  • Pitavastatin-d4 Sodium Salt
    匹伐他汀-d4钠盐
    TMIJ-0119
    Pitavastatin-d4 Sodium Salt 是 Pitavastatin Sodium Salt 的氘代化合物。Pitavastatin Sodium Salt 的 CAS 号为 574705-92-3。
    • 待询
    20日内发货
    规格
    数量
  • (±)9-HODE
    T3655998524-19-7
    (±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of rabbit reticulocytes. [1][2] Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs and HODEs. [3][4]
    • 待估
    35日内发货
    规格
    数量
  • (±)14(15)-EET
    (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-EET
    T35463197508-62-6
    (±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg kg prior to occlusion or reperfusion.[5] Reference:[1]. Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem. Biophys. Res. Commun. 104(3), 916-922 (1982).[2]. Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J. Biol. Chem. 257(7), 3771-3781 (1982).[3]. Jiang, J.-X., Zhang, S.-J., Xiong, Y.-K., et al. EETs attenuate ox-LDL-induced LTB4 production and activity by inhibiting p38 MAPK phosphorylation and 5-LO BLT1 receptor expression in rat pulmonary arterial endothelial cells. PLoS One 10(6), e0128278 (2015).[4]. Oltman, C.L., Weintraub, N.L., VanRollins, M., et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83(9), 932-939 (1998).[5]. Nithipatikom, K., Moore, J.M., Isbell, M.A., et al. Epoxyeicosatrienoic acids in cardioprotection: Ischemic versus reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 291(2), H537-H542 (2006).
    • 待估
    35日内发货
    规格
    数量
  • Subtilisin
    枯草杆菌蛋白酶, EC 3.4.21.14
    T783549014-01-1
    Subtilisin (EC 3.4.21.14) 是一种从细菌中提取的丝氨酸蛋白酶,可促进肝脏 LDL 受体 (LDLR)降解,可用于研究心血管疾病。
    • ¥ 147
    现货
    规格
    数量
  • Pitavastatin
    NK104, 匹伐他汀, NK 104, NK-104
    T7072147511-69-1
    Pitavastatin (NK-104) 是一种 3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂,具有降胆固醇和神经保护活性,抑制乙酸合成胆固醇,可减少氧化应激。Pitavastatin 是一种肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂,可用于研究冠状动脉粥样硬化、高胆固醇血症和急性冠脉综合征。Pitavastatin 结构不稳定,建议现用现配。
    • ¥ 123
    现货
    规格
    数量
  • Pinobanksin 3-acetate
    3-O-乙酰短叶松素, 3-O-Acetylpinobanksin
    TN296752117-69-8
    Pinobanksin 3-acetate (3-O-Acetylpinobanksin) 是一种短叶松素酯衍生物,是一种强抗氧化剂,存在于向日葵和蜂蜜中,可以抑制低密度脂蛋白的过氧化.
    • ¥ 745
    现货
    规格
    数量
  • Methyl protodioscin
    山药, 甲基原薯蓣皂甙, Smilax saponin B, NSC-698790
    T377154522-52-0
    Methyl protodioscin (Smilax saponin B) 是一种甾二糖苷,能诱导细胞周期阻滞,具有抗肿瘤活性。
    • ¥ 159
    现货
    规格
    数量
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