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LDLR Protein, Human, Recombinant (Avi & His), Biotinylated

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货号 TMPJ-00394

别名 Low-Density Lipoprotein Receptor, LDLR, LDL Receptor

Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.

LDLR Protein, Human, Recombinant (Avi & His), Biotinylated
其他形式的 “LDLR Protein, Human, Recombinant (Avi & His), Biotinylated”:
LDLR Protein, Human, Recombinant (His & Avi)
LDLR Protein, Cynomolgus, Recombinant (His)
LDLR Protein, Human, Recombinant (His)
LDLR Protein, Mouse, Recombinant (His)
LDLR Protein, Human, Recombinant (mFc)
LDLR Protein, Mouse, Recombinant (His), Biotinylated
LDLR Protein, Human, Recombinant (His), Biotinylated
LDLR Protein, Human, Recombinant (193D/A, His)

LDLR Protein, Human, Recombinant (Avi & His), Biotinylated

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Rating icon 还可以
SPR兼容缓冲液
货号 TMPJ-00394 别名 Low-Density Lipoprotein Receptor, LDLR, LDL Receptor

Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.

规格价格库存数量
5 μg
¥ 815
2-4周
10 μg
¥ 1,350
2-4周
20 μg
¥ 2,260
2-4周
50 μg
¥ 3,980
2-4周
100 μg
¥ 6,130
2-4周
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产品介绍

生物活性
产品描述
Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.
生物活性
Loaded Biotinylated Human LDL R-Avi-His on SA Biosensor, can bind Mouse PCSK9-His with an affinity constant of 4.97 nM as determined in BLI assay. (Regularly tested)  
研究背景
Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.
种属
Human
表达系统
HEK293 Cells
标签C-Avi-6xHis
蛋白编号P01130
氨基酸序列Ala22-Arg788
蛋白构建Ala22-Arg788
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM HEPES, 150 mM NaCl, pH 7.4.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名Low-Density Lipoprotein Receptor, LDLR, LDL Receptor
内毒素< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
化学信息
分子量95-140 KDa (reducing condition)
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

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