kinesin eg5

S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。

Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂，对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型， 能够抑制细胞有丝分裂，诱导形成单极纺锤体表型，介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性，对循环外周血单核细胞 (PBMC)有抑制作用。

Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂，IC50值为 14 μM。

Eg5-IN-1 是一种有效的驱动蛋白家族运动蛋白 (Eg5) 抑制剂，对 Eg5 的 IC50 值为 1.97 µM。Eg5-IN-1 可用于研究癌症。

HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.

Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during

BDPSB is a highly efficient photocontroller of mitotic kinesin Eg5 ATPase activity.

Dimethylenastron 是一种驱动蛋白Eg5抑制剂，IC50值为 200 nM。它可阻止具有单极纺锤体的细胞，所有染色体都以单极纺锤体方式附着在该纺锤体上。

K858 Racemic (K858) 是一种选择性有丝分裂驱动蛋白 Eg5 抑制剂，以 ATP 非竞争性方式起作用，IC50值为 1.3 μM。

(S)-Monastroll is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.

ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂，具有抗肿瘤活性。

AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Eg5 is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.

PVZB1194是一种联苯型激酶Eg5（亦称KIF11）抑制剂，与细胞周期相关，可以通过抑制Eg5的ATP酶活性导致细胞周期阻滞和细胞凋亡，从而显现抗癌潜力。该化合物与α4 α6变抗袋结合，展现ATP竞争性活性。