isoxazole

Isoxazole (1,2-oxazole) 是乙酰胆碱酯酶 (AChE) 的抑制剂。异恶唑的配体结合并抑制 Sxc-反转运蛋白。

Biotinylated isoxazole 是 Isoxazole 的生物素化衍生物，能够触发与 RNA 颗粒相关的聚集体形成。

5-Chloro-3-phenylbenzo[c]isoxazole 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66589，CAS号为 719-64-2。

methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate 靶向 MAPK。

TP748 是一种异恶唑，也是合成四环素的关键中间体。

3-Amino-5-methylisoxazole 是医药中间体，用于生产磺胺类药物。

Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂，是磺胺类抗生素。它靶向内皮素受体 A，抑制乳腺癌外显子释放。

5-(2-furyl)-N-propylisoxazole-3-carboxamide 是一种用作分子结构单元的化合物，被认为是 NMDA 受体的调节剂，已被证明对神经元细胞中谷氨酸诱导的兴奋性毒性和氧化应激具有保护作用。它也被发现具有抗炎活性，使其成为阿尔茨海默病和帕金森病等疾病的潜在治疗剂。

Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothelin receptor A with an IC50 value of 0.60 μM and endothelin receptor B with an IC50 value of 22 μM. Additionally, Sulfisoxazole diethanolamine has been found to inhibit the release of breast cancer exosomes by specifically targeting endothelin receptor A [1] [2].

Pyrisoxazole is a novel fungicide inhibitor of Sterol 14α-demethylase.

5-Methyl-3-phenylisoxazole-4-carbonyl chloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64868，CAS号为 16883-16-2。

5-Methyl-3-(2'-chlorophenyl)-4-isoxazolecarboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65275，CAS号为 23598-72-3。

5-Methyl-3,4-diphenylisoxazole 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66198，CAS号为 37928-17-9。

3,5-Dimethylisoxazole-4-boronic acid pinacol ester 是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

5-Methylisoxazole-4-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66496，CAS号为 42831-50-5。

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65267，CAS号为 3919-74-2。

Sulfisoxazole acetyl (Gantrisin) 是 Sulfisoxazole 的一种衍生物，是口服有效的二氢蝶酸合酶抑制剂。Sulfisoxazole acetyl 显示出抗菌作用。

ISX-9 (Isoxazole 9) 是一种神经干细胞分化的有效诱导剂，可诱导 Notch 激活的心外膜衍生细胞(NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入，并增加 NeuroD 表达。

PNZ5 是一个有效的、异恶唑类的、BET 的广泛抑制剂，有着类似(+)-JQ1 的高选择性和强效作用，其对 BRD4(1) 的 KD 值为 5.43 nM。

Clomazone (Magister) 是一种能够用于控制棉花，豌豆，南瓜，大豆，地瓜，烟草的一年生草和阔叶杂草的广谱抗菌剂。

Sulfacecole是一种作为抗菌剂的异噁唑基磺胺衍生物。

MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK-8245 displays similar potencies against human, rat and mouse SCD1 with IC50 values of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. MK-8245 exhibits a significant SCD inhibition in the rat hepatocyte assay which contains functional, active OATPs with IC50 of 68 nM, while being only weakly active in the HepG2 cell assay which is devoid of active OATPs with IC50 of ~1 μM. MK-8245 displays highly selective activity for the Δ-5 and Δ-6 desaturases (i.e., >100000 μM vs rat and human Δ5D and Δ6D as assessed in the HepG assay. in vivo: Administration of MK-8245 at 10 mg kg in mice exhibits a tissue distribution profile concentrated in the liver. It shows a liver-to-Harderian gland ratio of 21, suggesting a high degree of liver-targeting compared to a systemically distributed compound with liver-to-Harderian gland ratio of 1.5. Oral dosing of MK-8245 in mice, rats, dogs, and rhesus monkeys demonstrates that MK-8245 is distributed mainly to the liver, with low exposure in tissues associated with potential adverse events. The liver-to-skin ratios are >30:1 in all four species. Administration of MK-8245 to eDIO mice before the glucose challenge improves glucose clearance in a dose-dependent manner with ED50 of 7 mg kg.

VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物，靶向巨噬细胞，减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生，具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。

Mtb-IN-5（化合物(-)17j）是一种异恶唑类化合物，对结核分枝杆菌(Mtb)具有活性。它能够抑制宿主巨噬细胞内Mtb的呼吸及生物膜生长，且能够增强异烟肼(INH)对耐INH Mtb突变株的抑制效果。