ip3 receptor

2-Aminoethyl diphenylborinate (2-APB) 是细胞通透性的 IP3R 和 TRP 通道抑制剂，还抑制 store-operated Ca2+(SOC)通道。

(E)-GABAB receptor antagonist 1 是 GABAB receptor antagonist 1 的反式结构。(E)-GABAB receptor antagonist 1 降低 GABA 诱导的 IP3 (三磷酸肌醇) 产生，IC50 为 37.9 μM。GABAB receptor antagonist 1是选择性的 GABAB (γ-氨基丁酸) 受体的负变构调节剂。

(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.

Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。

ARN 11391是ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1)的增效剂，它直接作用于ITPR1，从而增强细胞内钙离子信号。ARN 11391还能增强表达突变型ITPR1细胞中的钙信号，这与SCA29型脊髓小脑共济失调有关。

RO2959 Hydrochloride (RO2959 HCl) 是选择性CRAC 通道抑制剂，IC50为 402 nM。它是人IL-2产生的有效抑制剂，有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1 Stim1通道介导的钙存储进入的有效阻滞剂，IC50为 25 nM。

Xestospongins and araguspongins, marine natural products originally isolated from sponges in the Pacific basin, exhibit vasodilatory effects. Inositol phosphates (IP) serve as crucial signal transduction messengers, activating IP3 receptors to facilitate Ca2+ release from intracellular stores. Araguspongin B specifically hinders the calcium-releasing function of inositol 1,4,5-trisphosphate at the receptor level within cerebral microsomes, demonstrating an inhibition concentration (IC50) of 0.6 µM. This potency places it nearly on par with xestospongin C in obstructing the IP3 receptor's activity.