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抑制剂&激动剂
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TargetMol产品目录中 "il 37"的结果
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TargetMol产品目录中 "

il 37

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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
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    TargetMol | Recombinant_Protein
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    TargetMol | Peptide_Products
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    TargetMol | Antibody_Products
  • NOD1-RIPK2-IN-1
    T201625
    NOD1-RIPK2-IN-1 (Compound 37) 作为一种针对NOD1-RIPK2信号通路的抑制剂,表现出对NOD1和PIPK2不同程度的抑制效果,其IC50值分别为42 nM和1.52 nM。此化合物还能有效降低促炎细胞因子IL-8的释放,适用于炎症及免疫疾病的相关研究。
    • 待询
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  • β-Defensin-2 (human) (trifluoroacetate salt)
    T35451
    β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-2 induces IL-31 production by human peripheral blood-derived mast cellsin vitrowhen used at a concentration of 10 μg/ml and by rat mast cellsin vivofollowing a 500 ng intradermal dose.4Expression of β-defensin-2 is increased in psoriatic skin and chronic wounds.5,6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 3.Niyonsaba, F., Ushio, H., Nakano, N., et al.Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokinesJ. Invest. Dermatol.127(3)594-604(2007) 4.Niyonsaba, F., Ushio, H., Hara, M., et al.Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cellsJ. Immunol.184(7)3526-3534(2010) 5.Huh, W.-K., Oono, T., Shirafuji, Y., et al.Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skinJ. Mol. Med. (Berl.)80(10)678-684(2002) 6.Butmarc, J., Yufit, T., Carson, P., et al.Human β-defensin-2 expression is increased in chronic woundsWound Repair Regen.12(4)439-443(2004)
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  • 1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
    T36452799268-65-8
    1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2 EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2- - dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.
    • 待估
    35日内发货
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  • LL-37 amide (trifluoroacetate salt)
    T38309
    LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination with a minimal agglutinating concentration (MAC) of 12.1 μg/ml. It is a chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that naturally express formyl peptide receptor-like 1 (FPRL1) and FPRL1-transfected HEK293 cells. LL-37 (10-15 μM) pretreatment of dengue virus type 2 (DENV-2) reduces its infectivity as well as levels of viral genomic RNA and NS1 antigen. In vivo, LL-37 inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of the inflammatory cytokines IL-1β, IL-6, and TNF-α, and improves survival in polybacterial septic mice.
    • 待估
    35日内发货
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  • Triptonide
    雷公藤内酯酮, PG 492, NSC 165677
    T5S105838647-11-9
    Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物,是一种 Wnt 信号抑制剂,其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。
    • ¥ 438
    In stock
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  • Cendakimab
    申达奇单抗, RPC4046, RPC 4046, CC93538, CC 93538, ABT-308, ABT308
    T769422151032-62-9
    Cendakimab (RPC4046) 是一种靶向 IL-13 的人源化抗体,通过抑制白细胞介素(IL)-13受体(IL13R-α1和IL13R-α2)的结合,选择性地靶向白细胞介素(IL)-13,可用于研究特应性皮炎。
    • ¥ 1980
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  • Citrullinated LL-37 1cit
    T80469
    Citrullinated LL-37 1cit 是一种Citrullinated形式的 LL-37 肽,保持了针对 human rhinovirus 的抗病毒 (antiviral) 功能,同时对S. aureus 表现出抗菌 (antibacterial) 活性。此外,Citrullinated LL-37 1cit 能够降低 RV1B 诱导的 IL-8、CCL5 和 IL-6mRNA 水平。
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  • Citrullinated LL-37 2cit
    T80470
    Citrullinated LL-37 2cit是瓜氨酸化的LL-37肽,在10 μg mL浓度下可减弱LL-37对HRV活性的抑制,并降低LL-37的抗菌效果。此外,Citrullinated LL-37 2cit能显著降低RV1B诱导的IL-8、CCL5和IL-6 mRNA水平,并对HRV诱导的CCL5分泌能力有中度抑制作用。
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