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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-IL-37 Polyclonal Antibody

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货号 TMAB-07661

Anti-IL-37 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IL-37。Anti-IL-37 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

Anti-IL-37 Polyclonal Antibody

Anti-IL-37 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07661

Anti-IL-37 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IL-37。Anti-IL-37 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,160
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100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-IL-37 Polyclonal Antibody is a Rabbit antibody targeting IL-37. Anti-IL-37 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
Ig Type
IgG
反应种属
Human
应用IHC-PIHC-FrIFELISA
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm; cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
组织特异性In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
Recombinant Protein: human IL37 protein
抗原种属
Human
基因名称
IL37
基因ID
27178
蛋白名称
Interleukin-37
Uniprot ID
Q9NZH6
功能
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
化学信息
分子量Theoretical: 24 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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