heptapeptide

Dermorphin 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。

Dermorphin TFA 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。

Acetyl sh-heptapeptide-1，一种多肽，有效对抗面部老化。

Acetyl heptapeptide-4，一种抗过敏(antiallergic)生物活性肽，已报道作为化妆品成分使用。

Phalloidin 是一种在鹅膏菌中发现的双环七肽，参与 F-肌动蛋白染色。 Phalloidin 是一种肌动蛋白不可逆聚合成微丝的化合物。Phalloidin 可干扰细胞的运动和生长，可用于标记脑血管。

Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations. Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM. Note that this metabolite should not be confused with the plant flavonoid of the same name.

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

Unguisin B is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.

Eptifibatide (Eptifibatide Acetate) 是一种糖蛋白 IIb/IIIa 抑制剂类的抗血小板药物，是一种由 6 个氨基酸和一个巯基丙酰基残基构成的环状七肽。

Eptifibatide acetate (148031-34-9 free base) (Eptifibatide acetate) 是一种糖蛋白 IIb/IIIa 抑制剂类的抗血小板药物，是一种由 6 个氨基酸和一个巯基丙酰基残基构成的环状七肽。

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性，因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮，是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。

LH-RH (4-10)，一种性腺激素释放激素(LHRH)的主要降解产物，属于七肽类，主要在巨噬细胞和II型肺细胞中产生。

Substance P (5-11) 是 Substance P (Substance P ) 的 C 端七肽 ，是一种神经肽，可以与NK-1速激肽受体结合。

Amyloid-Forming peptide GNNQQNY是由酵母蛋白Sup35的N-末端朊病毒决定结构域中得来的七肽段，具有生物活性，并能形成淀粉样纤维。它的详细原子低聚结构之研究，使其成为揭示早期聚集阶段的理想模型。GNNQQNY二聚体以三种稳定构形存在：寄存器内并排、寄存器外并排和反向并排。对准的平行二聚体其β-pleated sheet结构中肽链间氢键较少，强调了疏水作用的重要性，相较于反向并排结构有更高的构象熵。

PapRIV是最初从B. cereus分离出的一种群体感应七肽。它被转译为一个48-氨基酸多肽，由NprB蛋白酶在细胞外分泌和加工形成活性七肽。PapRIV（1-25 µM）在BV-2微胶质细胞中诱导IL-6和TNF-α的产生，并促使NF-κB转移。

Spinorphin 是一种脑非肽降解酶抑制剂，能够抑制氨基肽酶、二肽基氨基肽酶III、血管紧张素转换酶和脑非肽酶。它可用于研究疼痛的缓解。

Alexamorelin Met 1 is one of the metabolites of alexamorelin. The heptapeptide Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (Alexamorelin) is a synthetic molecule which inhibits growth hormone secretagogue binding in vitro.

Super-tdu (1-31) TFA is an endogenous ligand of heptapeptide receptor and has a strong anti-analgesic effect.

Kemptide 是一种 cAMP 依赖性蛋白激酶的特异性底物，是一种合成的七肽。

Kemptide TFA (65189-71-1 free base) 是一种合成七肽，可作为 cAMP 依赖性蛋白激酶 (PK) 的底物。

Dermorphin Analog, derived from the natural heptapeptide μ-opioid receptor agonist found in amphibian skin, labels m-opioid receptors with high affinity and selectivity in r. The dermorphin-derived peptide [Dmt1] Dermorphin Analog exhibits these properties effectively.

Lagatide is a synthetic heptapeptide that has antisecretory activity.

DTX-P7 是一种由 Docetaxel (DTX) 和一个七肽 (P7) 组成的多肽药物偶联物 (PDC)，通过破坏 Hsp90 蛋白，诱导未折叠蛋白反应，进而导致细胞凋亡。

Vaccarin C (Compound VIII) 是一种环庚肽，显示出显著的抗真菌活性，对病原真菌和皮肤真菌M. audouinii及T. mentagrophytes的MIC为6 µg/mL。其对道尔顿淋巴瘤腹水 (DLA) 和埃利希腹水癌 (EAC) 细胞系展现出较强的细胞毒性，CTC50分别为3.35和5.72 μmol/L。