heptapeptide

Dermorphin 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。

Dermorphin TFA 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。

Acetyl sh-heptapeptide-1，一种多肽，有效对抗面部老化。

Acetyl heptapeptide-4，一种抗过敏(antiallergic)生物活性肽，已报道作为化妆品成分使用。

Phalloidin 是一种在鹅膏菌中发现的双环七肽，参与 F-肌动蛋白染色。 Phalloidin 是一种肌动蛋白不可逆聚合成微丝的化合物。Phalloidin 可干扰细胞的运动和生长，可用于标记脑血管。

Jmv 170 is the C-terminal heptapeptide of cholecystokinin. It has partial agonist CCK activity on pancreatic amylase release.

MK 0852 is the platelet GP IIb IIIa cyclic heptapeptide antagonist.

H 256 is a pepsin heptapeptide inhibitor.

HP 228 is a heptapeptide by inhibits the induction of nitric oxide synthase.

CHEC-7 is a neuroprotective cyclic heptapeptide.

Cyclo-cadagac is a cyclic heptapeptide.

KNI 122is a heptapeptide analog.

Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations. Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM. Note that this metabolite should not be confused with the plant flavonoid of the same name.

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

Unguisin B is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.

Eptifibatide (Eptifibatide Acetate) 是一种糖蛋白 IIb IIIa 抑制剂类的抗血小板药物，是一种由 6 个氨基酸和一个巯基丙酰基残基构成的环状七肽。

Eptifibatide acetate (148031-34-9 free base) (Eptifibatide acetate) 是一种糖蛋白 IIb IIIa 抑制剂类的抗血小板药物，是一种由 6 个氨基酸和一个巯基丙酰基残基构成的环状七肽。

TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells.

WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性，因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮，是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。

Microcystin-LY 是一种铜绿微囊藻蓝藻的环状七肽毒素，可作为 Nrf2通路的激活剂引起氧化应激反应,在3μM 时诱导效果非常明显。

LH-RH (4-10)，一种性腺激素释放激素(LHRH)的主要降解产物，属于七肽类，主要在巨噬细胞和II型肺细胞中产生。

Substance P (5-11) 是 Substance P (Substance P ) 的 C 端七肽 ，是一种神经肽，可以与NK-1速激肽受体结合。

Met-Enkephalin-Arg-Phe 是一种天然七肽，具有镇痛活性。