hepatocyte injury

Arjunolic acid 是分离自蓝莓的皂苷，具有抗氧化、抗菌和抗炎症等多种生物活性，在保护细胞和组织免受活性氧的有害作用中发挥重要作用。

Thioacetamide（TAA）是一种间接性肝毒剂，常用于诱导实验性肝损伤。TAA 经 CYP2E1 代谢生成活性代谢物，与蛋白质和脂质共价结合，引发氧化应激和小叶中央坏死，导致肝细胞坏死及以 M1 M2 巨噬细胞为主的炎症反应，常用于构建慢性肝纤维化和肝性脑病以及肝癌模型。

TCPOBOP 是一种组成型雄烷受体激动剂，可诱导强大的肝细胞增殖和肝肿大。它通过改变 Bcl-2 蛋白来减少 Fas 诱导的小鼠肝损伤。

Homoplantaginin 是来自中药荔枝草的一种类黄酮，具有抗炎和抗氧化活性。

PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.

Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury, it shows anti-hepatitis B virus (HBV) activity.

Retrorsine 特异性地抑制肝细胞增殖，并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。

Isotaxiresinol prevents d-GalN LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma

Kaerophyllin ( (-)-Kaerophylin) 是一种从中药柴胡中分离出的木酚素，抑制肝细胞凋亡小体激活肝星状细胞，通过抑制肝脏炎症和抑制 HSC 活化来保护大鼠肝脏免受 TAA 引起的损伤和纤维化。

Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.