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TargetMol产品目录中 "

glomerulonephritis

"的结果
  • 抑制剂&激动剂
    11
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    5
    TargetMol | Recombinant_Protein
  • 天然产物
    3
    TargetMol | Natural_Products
  • R-268712
    T16708879487-87-3
    R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。
    • ¥ 378
    In stock
    规格
    数量
  • Edralbrutinib
    TG-1701
    T632721858206-58-2In house
    Edralbrutinib (TG-1701) 是有效的BTK抑制剂,具有抗癌活性,可用于治疗肿瘤、免疫系统疾病、血液及淋巴系统疾病。Edralbrutinib可用于研究膜性肾小球肾炎和视神经脊髓炎。
    • ¥ 479
    In stock
    规格
    数量
  • 3-Hydroxykynurenamine
    T6818299362-47-7In house
    3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1 NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall ameliorating immune-mediated glomerulonephritis and renal dysfunction.This compound is unstable in powder form and other related salt forms are recommended.
    • ¥ 10600
    3-6月
    规格
    数量
  • CT52923
    T60226205256-55-9
    CT52923是一种选择性、口服活性的血小板衍生生长因子受体(PDGFR)拮抗剂,以ATP竞争性抑制作用功能。它适用于多种病理性疾病的研究,包括动脉粥样硬化、肾小球肾炎、肝硬化、肺纤维化和癌症。
    • ¥ 108
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • CK2-IN-4
    T73375313985-59-0
    CK2-IN-4 是一种蛋白激酶 (CK2) 抑制剂 ,IC50 值为 8.6 µM。 CK2-IN-4 具有潜在的抗癌啊和抗炎活性,可用于研究病毒感染和肾小球肾炎的疾病。
    • ¥ 137
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • CC 401 dihydrochloride
    T36673
    High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication. Uehara et al (2004) c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 78 324 PMID:15316358 |Uehara et al (2005) JNK mediates hepatic ischemia reperfusion injury. J.Hepatol. 42 850 PMID:15885356 |Ma et al (2007) A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J.Am.Soc.Nephrol. 18 472 PMID:17202416 |Ma et al (2009) Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab.Invest. 89 470 PMID:19188913 |Zhang et al (2015) The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication. J.Med.Virol. 87 2135 PMID:26058558 |Vasilevskaya et al (2015) Inhibition of JNK sensitizes hypoxic colon cancer cells to DNA-damaging agents. Clin.Cancer.Res. 21 4143 PMID:26023085
    • ¥ 1833
    待询
    规格
    数量
  • Armepavine
    亚美罂粟碱, R-Armepavine, (-)-Armepavine
    T3775524-20-9
    Armepavine (R-Armepavine) 是来自Nelumbo nucifera 的活性化合物,能够抑制 TNF-α 诱导的MAPK 和NF-κB 信号级联反应。它不仅对人外周血单核细胞具有抗炎作用,且对 T 淋巴细胞和狼疮肾炎小鼠也具有免疫抑制作用。
    • ¥ 2430
    5日内发货
    规格
    数量
  • Skimmin
    茵芋苷, Skimmine
    T386993-39-0
    Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中,能够抑制免疫复合物的沉积,具有抗炎作用。
    • ¥ 189
    In stock
    规格
    数量
  • Benzylthiouracil
    6-苄基-2-硫脲嘧啶, 6-Benzyl-2-thiouracil
    T602686336-50-1
    Benzylthiouracil (6-Benzyl-2-thiouracil) 诱导 Graves 病患者的 ANCA 相关肾小球肾炎,可用于研究甲状腺功能亢进症。
    • ¥ 137
    In stock
    规格
    数量
  • D-Mannuronic acid sodium
    D-甘露糖醛酸单糖
    T78492921-56-2
    D-Mannuronic acid sodium,一种可从Macrocystis pyrifera中分离得到的化合物,显示出在自身免疫性脑脊髓炎(EAE)、佐剂性关节炎(AIA)、肾病综合征以及急性肾小球肾炎的研究中具有潜在应用价值。
    • 待询
    规格
    数量
  • NLRP3-IN-25
    T870162660230-90-8
    NLRP3-IN-25(compound 32)为口服有效的NLRP3抑制剂,表现出抗炎作用。该化合物能缓解阿霉素诱发的小鼠肾小球肾炎所导致的肾脏损伤。在THP-1细胞中,NLRP3-IN-25抑制IL-1β分泌的IC50值达21 nM。
    • 待询
    10-14周
    规格
    数量
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