df-2

Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.

Gliquidone (AR-DF 26) 是一种磺酰脲类的抗糖尿病药物，可用于2型糖尿病的研究。

YTHDF2-IN-1 (Compound CK-75) 是一种 YT521-B 同源域家族 2 (YTHDF2) 的抑制剂，其 Kd 值为 26.2 μM，能够阻止 YTHDF2 与 m6A RNA 的作用。YTHDF2-IN-1 可阻碍 JAR 细胞的集落形成，并在多种癌细胞中展现出抗增殖活性（IC50 为微摩尔）。此外，它在 G0 G1 期阻滞细胞周期，并诱导 K562 细胞发生凋亡 (apoptosis)。

Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.

Ladarixin is a dual, non-competitive allosteric inhibitor of CXCR1 and CXCR2 interleukin8 (IL-8a and IL-8b, respectively). The efficacy of CXCR1/2 inhibition prevents inflammation and autoimmune-mediated islet damage.

AZ-DF 265 is a hypoglycaemic drug which stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels and displaces [3H]-glibenclamide from the sulphonylurea receptor.

DC-Y13-27 是一种 DC-Y13 的衍生物，是一种有效的 YTHDF2 抑制剂 (KD: 37.9 μM)。DC-Y13-27 具有抗肿瘤活性，可增强放疗和免疫疗法对肿瘤的响应。