bms8

BMS-8 抑制PD-1 PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合，促使形成 PD-L1 同源二聚体，进而阻断 PD-L1 与 PD-1 的相互作用。

BMS817378 是一种有效的选择性 MET 抑制剂 (IC50 : 1.7 nM)。

BMS-817399 是一种具有口服活性的 CCR1 拮抗剂，具有结合亲和力和趋化性抑制效力的 IC50，可用于类风湿性关节炎的研究。

BMS-823778 是一种高效的 11β-羟基类固醇脱氢酶 1 型（11β-HSD-1）的抑制剂，可用于研究 2 型糖尿病。

BMS 777607 (BMS 817378) 是 Met-related 抑制剂，能够抑制 c-Met (IC50:3.9 nM)，Axl (IC50:1.1 nM)，Ron (IC50:1.8 nM) 和 Tyro3 (IC50:4.3 nM) 的活性。

Alvespimycin hydrochloride (BMS 826476) 是一种Hsp90抑制剂，结合到 Hsp90，EC50为 62±29 nM。

Delcasertib (KAI-9803) 是一种有效且选择性的 δ-蛋白激酶 C (δPKC) 抑制剂，可改善急性心肌梗死动物模型的缺血再灌注损伤。

(Rac)-BMS-816336 (Compound 6n) 是 BMS-816336 的外消旋体。(Rac)-BMS-816336 是人和小鼠 11β-羟类固醇脱氢酶 1 型 (11β-HSD1) 的有效抑制剂，其 IC50分别为 10 nM 和 68 nM，并具有良好的代谢稳定性 。

BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

BMS-818251 是一种高效的HIV-1侵入性小分子抑制剂，其EC50为0.019 nM。相比于BMS-626529，BMS-818251在208-HIV-1毒株的交叉分支组上展示出超10倍的效力。该化合物通过与保守的β20-β21发夹结构中的gp120残基相互作用来增强效力。

BMS-833923 (XL-139) 是一种口服生物可利用的 Smoothened 拮抗剂，以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合，IC50为21 nM。

BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki o

BMS-856 is a compound that inhibits the activity of 17beta-HSD3 enzyme.

BMS-813160 是CCR2 CCR5双重拮抗剂。有用于心血管的研究潜力。

BMS-820132 是一种葡萄糖激酶 (glucokinase) 激活剂 (AC50: 29 nM)。

Fce 28260 is a 5 alpha-reductase inhibitor.

BMS-870145 is a potent and selective P2Y1 purinergic receptor antagonist..

SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

BMS-883559 is a novel inhibitor of the influenza nucleoprotein (INF-NP).

BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.

CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.

BMS-830216 is a nonbasic melanin hormone receptor 1 antagonist and a prodrug of BMS-819881.

AJ-108235 is a novel inhibitor of long chain fatty acid elongase 6 (ELOVL6).

(R)-FTY-720 Vinylphosphonate is a sphingosine 1-phosphate type 1 (S1P1) receptor agonist and lacks anti-apoptotic activity.