aminopeptidase m

Aminopeptidase M 抑制对多种疾病（例如高度血管化的癌症类型）具有重要意义。

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.

Leucylmethionine is a substrate for aminopeptidase M.