alk in 6

ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).

ALK5-IN-6 是 ALK5 的有效抑制剂。 ALK5-IN-6 具有潜力进行 TGF-β 相关疾病和病症的研究，包括但不限于肿瘤、炎症性疾病、纤维化疾病、自身免疫性疾病等。其中转化生长因子 β (TGF-β) 是一种多功能细胞因子，通过细胞表面的复杂受体信号通路以自分泌、旁分泌和内分泌的方式参与调控细胞增殖、分化和凋亡。

CEP-28122 mesylate salt (1022958-60-6 free base) 是一种高选择性的口服活性 ALK 抑制剂(在基于酶的 TRF 测定中，IC50：1.9 nM)。

Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1].