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Anti-BMPR1A/ALK-3 Antibody (6X147)
还可以产品编号 TMAY-03081
别名 SKR5, CD292, bone morphogenetic protein receptor, type IA, ALK3, ACVRLK3, 10q23del
Anti-BMPR1A/ALK-3 Antibody (6X147) 是一种 Rabbit 抗体，靶向 BMPR1A/ALK-3。Anti-BMPR1A/ALK-3 Antibody (6X147) 可用于 ELISA。
Anti-BMPR1A/ALK-3 Antibody (6X147)
Anti-BMPR1A/ALK-3 Antibody (6X147)
还可以产品编号 TMAY-03081 别名 SKR5, CD292, bone morphogenetic protein receptor, type IA, ALK3, ACVRLK3, 10q23del
Anti-BMPR1A/ALK-3 Antibody (6X147) 是一种 Rabbit 抗体，靶向 BMPR1A/ALK-3。Anti-BMPR1A/ALK-3 Antibody (6X147) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,289 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-BMPR1A/ALK-3 Antibody (6X147) is a Rabbit antibody targeting BMPR1A/ALK-3. Anti-BMPR1A/ALK-3 Antibody (6X147) can be used in ELISA. |
| 别名 | SKR5, CD292, bone morphogenetic protein receptor, type IA, ALK3, ACVRLK3, 10q23del |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6X147 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse ALK-3 / BMPRIA (rM ALK-3 / BMPRIA; TMPY-01374; NP_033888.2; Met 1-Arg 152). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. ALK-3/BMPR1A is expressed in the epithelium during branching morphogenesis. Deletion of BMPR1A in the epithelium with an Sftpc-cre transgene leads to dramatic defects in lung development. ALK-3 and ALK-6 share a high degree of homology, yet possess distinct signaling roles. The transforming growth factor (TGF)-beta type III receptor (TbetaRIII) enhanced both ALK-3 and ALK-6 signaling. TbetaRIII associated with ALK-3 primarily through their extracellular domains, whereas its interaction with ALK-6 required both the extracellular and cytoplasmic domains. ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK-3 was specifically deficient in expressing TGFbeta2, an established paracrine mediator of cushion morphogenesis. Hence, ALK-3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse ALK-3 / BMPRIA protein (TMPY-01374) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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