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Cat. No.	Product Name	Target	Signaling Pathways
T40870	Leukotriene E4 LTE4	Endogenous Metabolite	Metabolism
	Leukotriene E4 (LTE4)（LTE4）通过二肽酶对LTD4 上的作用生成，是过敏性休克慢反应物质（SRS-A）的成分之一。LTE4 存在于血浆和尿液中，可用于检测哮喘。
T14326	AS-35	Others	Others
	AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergic activities.
T27877	LY 163443 LY163443,LY-163443
	LY 163443 is an dual receptor antagonist of LTD4 and LTE4.
T38062	N-acetyl Leukotriene E4 N-acetyl Leukotriene E4
	N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).
T27904	LY 245769 LY-245769,LY245769
	LY 245769 is an inhibitor of leukotriene E4 (LTE4).
T37494	11-trans Leukotriene E4 11-trans Leukotriene E4
	Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
T37262	14,15-Leukotriene E4 14,15-Leukotriene E4
	Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils...
T38129	Leukotriene F4 LTF4
	LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]
T63291	Pranlukast hemihydrate
	Pranlukast hemihydrate 是选择性的、高效的、竞争性的 leukotriene 拮抗剂。Pranlukast 能够抑制 [3H]LTE4 (Ki: 0.63±0.11 nM)，[3H]LTD4 (Ki: 0.99±0.19 nM)和 [3H]LTC4 (Ki: 5640±680 nM)与肺膜结合。
T0694	Pranlukast 普鲁司特,ONO-1078,普仑司特	Leukotriene Receptor; IL Receptor; Others; TNF; NF-κB; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
	Pranlukast (ONO-1078) 是一种半胱氨酰白三烯受体 1 拮抗剂，可拮抗或减少支气管痉挛，用于哮喘研究。
T16739	RG-12525 NID 525	Leukotriene Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Metabolism
	RG-12525（NID 525）是一种可口服且具有选择性和竞争性的白三烯 D （LTD）拮抗剂，对 LTC4，LTD4 和 LTE4 诱导的豚鼠薄壁带收缩有抑制作用，IC50 值分别为 2.6 nM，2.5 nM 和 7 nM。RG-12525 对 CYP3A4 有抑制作用， Ki 值为 0.5 µM。RG-12525 是一种新型高效的 PPAR-γ 激动剂（IC50 值约为 60 nM），具有物种特异性，可用于研究哮喘。
T37980	N-methyl Leukotriene C4 N-methyl Leukotriene C4
	Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot...
T15647	Tipelukast MN 001,KCA 757	Leukotriene Receptor	GPCR/G Protein
	Tipelukast (KCA 757) 是一种新型可口服的白三烯受体 (leukotriene receptor) 拮抗剂，是具有抗炎活性，可减少纤维化，下调 TIMP-1、1 型胶原蛋白。Tipelukast 可用于研究哮喘疾病。

化合物

Cat.No: T40870

Synonym: LTE4

Target: Endogenous Metabolite

Cat.No: T14326

Target: Others

Cat.No: T27877

Synonym: LY163443,LY-163443

N-acetyl Leukotriene E4

Cat.No: T38062

Synonym: N-acetyl Leukotriene E4

Cat.No: T27904

Synonym: LY-245769,LY245769

11-trans Leukotriene E4

Cat.No: T37494

Synonym: 11-trans Leukotriene E4

14,15-Leukotriene E4

Cat.No: T37262

Synonym: 14,15-Leukotriene E4

Cat.No: T38129

Synonym: LTF4

Pranlukast hemihydrate

Cat.No: T63291

Cat.No: T0694

Synonym: 普鲁司特,ONO-1078,普仑司特

Target: Leukotriene Receptor, IL Receptor, Others, TNF, NF-κB, LTR

Cat.No: T16739

Synonym: NID 525

Target: Leukotriene Receptor, PPAR

N-methyl Leukotriene C4

Cat.No: T37980

Synonym: N-methyl Leukotriene C4

Cat.No: T15647

Synonym: MN 001,KCA 757

Target: Leukotriene Receptor

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