7α-hydroxylase

Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物，能够预防胆结石的形成。

Ketoconazole (R-41400) 是一种具有广谱抗真菌活性的咪唑类（imidazole）抗真菌药物，主要通过抑制真菌细胞膜中麦角固醇（ergosterol）的生物合成发挥作用。Ketoconazole 通过抑制真菌细胞色素 P450 依赖酶 lanosterol 14α-脱甲基酶（CYP51），阻断 lanosterol 向 ergosterol 的转化，导致细胞膜结构与通透性受损，从而抑制真菌生长并产生抗真菌作用。此外，Ketoconazole 也是一种非选择性细胞色素 P450（CYP）抑制剂，尤其可抑制人类 CYP3A4 等药物代谢酶。在内分泌方面，Ketoconazole 还可抑制多种类固醇合成相关酶（ CYP17A1、CYP11A1）。

Pilocarpine Hydrochloride (NSC 5746 HCl) 是一种 M3 型毒蕈碱乙酰胆碱受体激动剂。Pilocarpine Hydrochloride 用于制作癫痫实验模型。

GSK2945 is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.

GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.

GSK2945 hydrochloride 是一种叔胺，是一种高特异性的 Rev-erbα/REV-ERBα(小鼠/人反向成红细胞病病毒α) 拮抗剂，他们的 EC50 值分别为 21.5 μM 和 20.8 μM。GSK2945 hydrochloride 能够提高胆固醇 7α-羟化酶 (CYP7A1) 水平和胆固醇代谢。

5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.

Tauroursocholic acid (TUCA) 是一种牛磺酸结合形式的胆汁酸，源自ursocholic acid，并为taurocholic acid (TCA) 的7β-hydroxy对映体。与TCA不同，TUCA不抑制HMG-CoA reductase或细胞色素P450 (CYP) 异构体CYP7A1，即胆固醇7α-hydroxylase。在胆管癌患者中，TUCA的胆汁水平高于良性胆道疾病患者。