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FGF-8b Protein, Human, Recombinant
Synonyms: NEWENTRY, KAL6, HH6, HBGF-8, fibroblast growth factor 8 (androgen-induced), FGF-8, AIGF货号 TMPY-06986 一键复制产品信息
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In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
FGF-8b Protein, Human, Recombinant
一键复制产品信息 很棒SPR兼容缓冲液
货号 TMPY-06986
别名 NEWENTRY, KAL6, HH6, HBGF-8, fibroblast growth factor 8 (androgen-induced), FGF-8, AIGF
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 546 | 3日内发货 | |
| 10 μg | ¥ 893 | 3日内发货 | |
| 20 μg | ¥ 1,480 | 3日内发货 | |
| 50 μg | ¥ 2,930 | 现货 | |
| 100 μg | ¥ 5,010 | 5日内发货 | |
| 200 μg | ¥ 8,510 | 5日内发货 |
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产品介绍
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化学信息
储存&溶解度
| 产品描述 | In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning. |
| 生物活性 | Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.4-1.6 μg/mL. |
| 研究背景 | In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning. |
| 种属 | Human |
| 表达系统 | E. coli |
| 标签 | Tag Free |
| 蛋白编号 | P55075-3 |
| 蛋白构建 | A DNA sequence encoding the human FGF8b (P55075-3) (Gln23-Arg215) was expressed with an initial Met. |
| 蛋白纯度 | > 95 % as determined by SDS-PAGE. |
| 蛋白性状 | Lyophilized powder |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. . Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| 复溶方法 | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| 别名 | NEWENTRY, KAL6, HH6, HBGF-8, fibroblast growth factor 8 (androgen-induced), FGF-8, AIGF |
| 内毒素 | Please contact us for more information. |
| 分子量 | The recombinant human FGF8b consists 194 amino acids and predicts a molecular mass of 22.5 kDa. |
| 运输方式 | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| 存储 |
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