fibroblast growth factor 8

Sirtuinmodulator 8 是一种沉默调节蛋白 (sirtuin) 的调节剂，能够激活 Sirtuin 的活性。它显著下调单核细胞趋化蛋白-1 (MCP-1) 的表达，并上调成纤维细胞生长因子 21 (FGF21) 的表达。同时，Sirtuinmodulator 8 可调控与炎症和代谢相关的基因表达，展现出在代谢性疾病 (如糖尿病、肥胖) 及炎症性疾病研究中的潜力。

ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8).