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A33 Protein, Human, Recombinant (His)

产品编号 TMPY-02012

别名: glycoprotein A33 (transmembrane), A33

A33 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q99795-1.

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A33 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 2,270		5日内发货
500 μg	￥ 12,400		5日内发货

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生物活性	Testing in progress
产品描述	A33 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q99795-1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q99795-1
别名	glycoprotein A33 (transmembrane), A33
蛋白构建	The extracellular domain of Human GPA33 (Q99795-1) (Met 1-Val 235) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	25 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I membrane protein that is expressed in the normal gastrointestinal epithelium and 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Heath J.K., et al., 1997, Proc. Natl. Acad. Sci. USA. 94:469-74. 2. Ritter G., et al., 1997, Biochem. Biophys. Res. Commun. 236:682-6. 3. Frey,D. et al., 2008, Cancer Biother Radiopharm 23 (1):65-73. 4. Rageul,J. et al., 2009, Int J Cancer 125 (12):2802-9.

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Keywords

A33 Protein, Human, Recombinant (His) glycoprotein A33 (transmembrane) A 33 A-33 glycoprotein A33 transmembrane A33 recombinant recombinant-proteins proteins protein

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