Name: Tovetumab
Brand: TargetMol
SKU: T76764
Price: 2980 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,980

现货

5 mg

¥ 6,690

现货

10 mg

¥ 8,870

现货

25 mg

¥ 13,300

现货

50 mg

¥ 17,900

现货

生物活性

产品描述	Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
体外活性	方法：Tovetumab (0.001-10 nM，10 分钟) 处理MG-63 细胞，wb检测相关蛋白表达情况。结果：Tovetumab能够抑制 MG-63 细胞中配体诱导的人 PDGFRα 磷酸化。[2]
体内活性	方法：Tovetumab（0.6，6.0 ， 60 mg/kg，静脉注射）处理食蟹猴，观察其作用效果情况。结果：Tovetumab能够诱导食蟹猴钟血小板衍生生长因子 (PDGF-AA) 循环浓度增加 100 倍以上。[1]
别名	托维妥单抗, MEDI-575
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG2 kappa
推荐同型对照	Human IgG2 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	144.78 kDa
CAS No.	1243266-04-7

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Tovetumab