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PDGFRA Protein, Mouse, Recombinant (His)

产品编号 TMPY-05787

别名: CD140a, platelet-derived growth factor receptor, alpha polypeptide, Pdgfr-2, AI115593, platelet-derived growth factor receptor, α polypeptide

PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession number is P26618-2.

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PDGFRA Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 2,270		5日内发货
1 mg	￥ 24,900		5日内发货

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生物活性

技术参数

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized Mouse PDGFRA His at 2 μg/ml (100 μl/well) can bind Cynomolgus PDGF-B mFc, the EC50 of Cynomolgus PDGF-B mFc is 150-700 ng/mL.
产品描述	PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession number is P26618-2.

种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P26618-2
别名	CD140a, platelet-derived growth factor receptor, alpha polypeptide, Pdgfr-2, AI115593, platelet-derived growth factor receptor, α polypeptide
蛋白构建	The Mouse PDGFRA (NP_001334647.1) (Met1-Ala528)
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	57.87 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Oseini AM,et al.(2009) PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma? Expert Opin Ther Targets. 13(4): 443-54. 2. Meister M,et al.(2009) Expression and mutational status of PDGFR in thymic tumours. Anticancer Res. 29(10): 4057-61. 3. Martinho O,et al.(2009) Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 101(6): 973-82.

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Keywords

PDGFRA Protein, Mouse, Recombinant (His) CD140a platelet-derived growth factor receptor, alpha polypeptide Pdgfr-2 AI115593 AI 115593 AI-115593 platelet-derived growth factor receptor, α polypeptide recombinant recombinant-proteins proteins protein

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