SRI-31142 is a proposed brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies utilizing intracranial self-stimulation (ICSS), SRI-31142 does not produce the abuse-related effects observed with cocaine and GBR-12935. Instead, at effective doses, it reduces ICSS responding and dopamine levels in the nucleus accumbens (NAc). Additionally, SRI-31142 can prevent cocaine-induced increases in ICSS and NAc dopamine.