SK56 is an inhibitor of the GSDMD-NT pore. It prevents pyroptosis and the release of pyroptosis-related cytokines in macrophages and human peripheral blood leukocytes. In an organoid-macrophage co-culture model, SK56 protects human alveolar organoids from extensive cell death. It can also prevent death from infectious shock in mice induced by LPS or cecal ligation and puncture. SK56 is applicable for research related to sepsis.