Name: SelDeg51
Brand: TargetMol
SKU: T219265
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	SelDeg51 is a selective FKBP51 PROTAC degrader with a Kd value of 18 nM and a maximum degradation (Dmax) of 90%. It induces proteasomal degradation of FKBP51 via the formation of the KBP51:SelDeg51:VCB ternary complex, thereby reactivating the glucocorticoid receptor signaling pathway. SelDeg51 is applicable in research on stress-related psychiatric disorders, chronic pain, and obesity.
靶点活性	FKBP51:18 nM (Kd)
体外活性	SelDeg51 (0.6-10 μM; 0-48 h) 在 HEK293T 细胞中以时间依赖性且可逆的方式降解 FKBP51，并对 FKBP12 表现出高选择性。SelDeg51 (250 nM) 还可增强 Dexamethasone 在 A549 细胞中诱导的内源性糖皮质激素受体靶基因 GILZ 和 FKBP5 的表达。

化学信息

分子量	1343.60
分子式	C₇₂H₉₁FN₈O₁₄S
CAS No.	3036372-80-9
Smiles	[C@@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC=C(OCC4=CN(CCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)[C@](C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C8=C(C)N=CS8)N=N4)C=C3)=O)CCCC1)(C9=CC(OC)=C(OC)C(OC)=C9)C%10CCCCC%10

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

SelDeg51