RP-182 acetate is a synthetic immunomodulatory peptide that exerts antitumor effects by targeting the mannose receptor CD206 on tumor-associated macrophages (TAM) surfaces, with a dissociation constant (Kd) of 8 μM. It induces a conformational change in the CD206 receptor, thereby activating NF-κB signaling and phagocytosis in TAMs with high CD206 expression. RP-182 acetate has dual functions: it activates classical NF-κB signaling, which triggers TNFα secretion and autocrine activation of TNF receptor 1 (TNFR1), leading to caspase 8 activation and apoptosis. This compound is used in research studies on pancreatic cancer and melanoma.