PPTN hydrochloride

Name: PPTN hydrochloride
Brand: TargetMol
SKU: T63534
Price: 395 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.80%

货号 T63534Cas号 1992047-65-0

PPTN hydrochloride 是有效的、高亲和力的、竞争性的、高度选择性的P2Y14受体拮抗剂 (KB: 434 pM)，但 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂活性，表现出抗炎和抗免疫作用。

PPTN hydrochloride

一键复制产品信息

很棒

纯度: 99.80%

货号 T63534Cas号 1992047-65-0

规格	价格	库存
1 mg	¥ 395	现货
5 mg	¥ 946	现货
10 mg	¥ 1,660	现货
25 mg	¥ 3,230	现货
50 mg	¥ 4,790	现货
100 mg	¥ 6,850	现货
500 mg	¥ 13,700	6-8周

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.80%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

PPTN hydrochloride AI Summary

PPTN hydrochloride exhibits diverse bioactivity and pharmacological profiles affecting various cellular and molecular targets. It shows both inhibitory and stimulatory effects on cell viability across different cell lines, including HEK293T, human fibroblasts, and U2OS cells, indicating cell-type specificity in its action. The compound influences the thermal stability of specific protein domains variably, enhancing stability in some (S229-K512, M626-G746) while decreasing it in others (M26-R383, E122-S403). It demonstrates complex interactions in GPCR beta-arrestin recruitment assays with receptors like FFAR4, APLNR, and GPR35, showing both agonistic and inhibitory effects. In a specific cellular interaction assay in CHO cells expressing human M1, it displayed potentiation with an affinity greater than 10000.0 nM. Notably, PPTN hydrochloride exhibits high affinity for the P2RY14 receptor with an IC50 of 0.5 nM. Additionally, it shows selectivity in various assays, including a 30.0% activity in FLT3 target, a Ki value of 2.3 nM for P2RY14 in HEK293 cells, and a Ki value of 884.3 nM for DRD3. These attributes suggest potential therapeutic relevance in diseases modulated by these targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12 or P2Y13 receptors, exhibiting anti-inflammatory and anti-immune effects.

化学信息

分子量	511.96
分子式	C₂₉H₂₅ClF₃NO₂
CAS No.	1992047-65-0
Smiles	Cl.OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 225 mg/mL (439.49 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9533 mL	9.7664 mL	19.5328 mL	97.6639 mL
5 mM	0.3907 mL	1.9533 mL	3.9066 mL	19.5328 mL
10 mM	0.1953 mL	0.9766 mL	1.9533 mL	9.7664 mL
20 mM	0.0977 mL	0.4883 mL	0.9766 mL	4.8832 mL
50 mM	0.0391 mL	0.1953 mL	0.3907 mL	1.9533 mL
100 mM	0.0195 mL	0.0977 mL	0.1953 mL	0.9766 mL