Name: Norgestomet
Brand: TargetMol
SKU: T19697
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

3-6月

50 mg

待询

3-6月

100 mg

待询

3-6月

生物活性

产品描述	Norgestomet is a synthetic progestin compound used in veterinary reproduction research. It acts through binding to progesterone receptors, with studies demonstrating that a 6 mg ear implant can inhibit estrus in cattle for a mean of 17 to 20 days depending on treatment timing. In neonatal ewes, chronic norgestomet exposure from birth permanently ablates endometrial gland development by suppressing epithelial estrogen receptor alpha expression and downregulating key paracrine growth factor signaling pathways, including HGF and FGFR2IIIb. This property makes norgestomet a valuable research tool for creating uterine gland knockout models and investigating steroid receptor regulation of reproductive tract morphogenesis.
体内活性	Norgestomet (NOR) 通过皮下植入方式，在新生羔羊出生时及出生后第14天给药，可永久性消除子宫内膜腺体形态发生（腺体生成），形成成年子宫腺体敲除表型。出生后第28天的组织学分析证实，该处理特异性抑制子宫内膜腺体生成，而对输卵管、子宫颈及阴道的组织结构无影响。该动物模型适用于研究子宫腺体在生殖生理中的功能机制。
别名	SC-21009, SC21009, SC 21009, Norprogesterone, Syncro-Mate B

化学信息

分子量	372.5
分子式	C₂₃H₃₂O₄
CAS No.	25092-41-5
Smiles	C[C@@]12[C@@](OC(C)=O)(C(C)=O)CC[C@]1([C@]3([C@]([C@@H](C)C2)([C@@]4(C(CC3)=CC(=O)CC4)[H])[H])[H])[H]
密度	1.14g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: Soluble

Norgestomet