NMDA receptor antagonist9 is a selective antagonist targeting NMDA receptors containing the GluN2B subunit, with a Ki value of 5.2 nM. It exhibits 9-fold selectivity for σ1 receptors, although it is less selective for σ2 receptors. NMDA receptor antagonist9 inhibits ion flow through NMDA receptors with the GluN2B subunit and is utilized in researching neurological disorders such as Alzheimer's and Parkinson's diseases.

GluN2B:5.2 nM (Ki)