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N-Phenylacrylamide

Name: N-Phenylacrylamide
Brand: TargetMol
SKU: T9322
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.99%

货号 T9322Cas号 2210-24-4

别名 N-苯基丙烯酰胺

N-Phenylacrylamide 通过荧光转酰胺法抑制人重组 TGM2。

N-Phenylacrylamide

一键复制产品信息

很棒

纯度: 99.99%

货号 T9322 别名 N-苯基丙烯酰胺Cas号 2210-24-4

N-Phenylacrylamide 通过荧光转酰胺法抑制人重组 TGM2。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 108	现货

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纯度: 99.99%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

N-Phenylacrylamide AI Summary

N-Phenylacrylamide is a bioactive inhibitor of human recombinant Transglutaminase 2 (TG2), with an IC50 value of 43000.0 nM based on fluorescent transamidation assay results. It exhibits various pharmacokinetic properties, including a half-life of 4.983 hours in phosphate buffer at pH 7.4 at a concentration of 50 uM in the presence of glutathione. It shows intrinsic clearance rates in human and rat hepatocytes of approximately 30.9 and 32.36 uL/min/(10^6 cells), respectively, indicating moderate metabolism and elimination in liver cells. Additionally, N-Phenylacrylamide inhibits several enzymes—such as West Nile virus NS2B-NS3 protease, Dengue virus serotype 2 NS2B-NS3 protease, Bovine thrombin, human and Escherichia coli MetAP, and wild-type Escherichia coli Mur enzymes—with inhibition rates of less than 15.0%. It also inhibits human FBPase by 17.0% at 500 uM. Furthermore, the compound demonstrates GSH reactivity and forms adducts, evident from RP-HPLC analysis, and shows a pseudo-first-order reaction with GSH at 37°C (K = 13.0 x 10^-3/min) with a half-life of 0.88 hours for GSH reactivity. In terms of thiol reactivity, N-Phenylacrylamide has a pseudo-first-order rate constant of 1.6 x 10^-4/s in a PBS/DMSO buffer environment. When tested against cysteine in PBS buffer using NMR assay, it has a half-life of 2.3 hours and a rate constant of 8.38 x 10^-5/s. Additionally, it shows a half-life of 4.75 hours in GSH reactivity assessment using DNTB and exhibits a Gibbs free energy change of 24.1 kcal/mol at 1 uM concentration within 120 minutes, with a pseudo-first-order rate constant of 3.87 x 10^-3/min and a half-life of 2.983 hours under pH 7.4 phosphate buffer conditions. N-Phenylacrylamide also manifests cytotoxicity against HeLa cells, with an EC50 greater than 100,000.0 nM, further highlighting its potential bioactivity and reactivity in various biological contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N-Phenylacrylamide inhibit human recombinant TGM2 by fluorescent transamidation assay.
靶点活性	TGase 2:43 µM
别名	N-苯基丙烯酰胺

化学信息

分子量	147.17
分子式	C₉H₉NO
CAS No.	2210-24-4
Smiles	C=CC(=O)Nc1ccccc1
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (373.72 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.7949 mL	33.9743 mL	67.9486 mL	339.7432 mL
5 mM	1.3590 mL	6.7949 mL	13.5897 mL	67.9486 mL
10 mM	0.6795 mL	3.3974 mL	6.7949 mL	33.9743 mL
20 mM	0.3397 mL	1.6987 mL	3.3974 mL	16.9872 mL
50 mM	0.1359 mL	0.6795 mL	1.3590 mL	6.7949 mL
100 mM	0.0679 mL	0.3397 mL	0.6795 mL	3.3974 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

TGM2 N-Phenylacrylamide NPhenylacrylamide N Phenylacrylamide

N-Phenylacrylamide

N-Phenylacrylamide