N-acetyl Dapsone

Name: N-acetyl Dapsone
Brand: TargetMol
SKU: T35903
Price: 987 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.83%

货号 T35903Cas号 565-20-8

别名 N-乙酰氨苯砜

N-acetyl Dapsone 是一种抗炎和抗菌化合物，广泛用于治疗麻风病、疟疾、痤疮和各种免疫疾病。

N-acetyl Dapsone

一键复制产品信息

很棒

纯度: 99.83%

货号 T35903 别名 N-乙酰氨苯砜Cas号 565-20-8

N-acetyl Dapsone 是一种抗炎和抗菌化合物，广泛用于治疗麻风病、疟疾、痤疮和各种免疫疾病。

规格	价格	库存
1 mg	¥ 987	现货
5 mg	¥ 2,550	现货
10 mg	¥ 3,970	现货
25 mg	¥ 6,430	现货
50 mg	¥ 8,660	现货
100 mg	¥ 11,600	现货
200 mg	¥ 15,700	现货

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纯度: 99.83%

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产品介绍

N-acetyl Dapsone AI Summary

N-acetyl Dapsone exhibits inhibitory activity against dihydropteroate synthase (SYN) from various microorganisms, showing moderate potency with the lowest IC50 against dihydropteroic acid synthase from Mycobacterium lufu, including DDS-resistant strains. This suggests its potential as an antifolate agent. The compound also shows inhibitory activity against Escherichia coli and Plasmodium berghei, albeit with higher IC50 values. In vitro, it inhibits Mycobacterium lufu's dihydropteroate synthase with a pC value of 5.15 and Escherichia coli's enzyme with an IC50 value of 5.75. Additionally, N-acetyl Dapsone exhibits various bioactivities: it activates and inhibits human muscle isoform 2 pyruvate kinase, modulates lipid storage in Drosophila cells, inhibits ELG1-dependent DNA repair in HEK293T cells, and induces DNA re-replication in various cell lines. It demonstrates antimycobacterial activity, being effective against DDS sensitive Mycobacterium smegmatis (MIC of 13.8 μg/mL) but not against DDS-resistant strains (MIC > 300 μg/mL). As an antimalarial, it prolongs survival in Plasmodium berghei-infected albino mice up to 3.5 weeks at a 400 mg/kg dose. In terms of pharmacokinetics and effects in rats, 50% of N-acetyl Dapsone is excreted in urine after 30 days of a single 400 mg/kg subcutaneous dose, with a half-life of 768 hours and a blood concentration of 1.3 μg/mL at the same dose. The compound shows activity against metallo-protein hemoglobin at 1.2 g/dL level post-administration at 400 mg/kg. Regarding anti-leprotic activity, it delays bacterial multiplication in the footpads of BALB/c mice infected with Mycobacterium leprae, starting at 60-75 days post-infection when administered at 0.01 g/100g of diet via feed for 90 days..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.
别名	N-乙酰氨苯砜

化学信息

分子量	290.34
分子式	C₁₄H₁₄N₂O₃S
CAS No.	565-20-8
Smiles	S(=O)(=O)(C1=CC=C(NC(C)=O)C=C1)C2=CC=C(N)C=C2
密度	1.362 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (103.33 mM), Sonication is recommended.

DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL (1.72 mM), Sonication is recommended.

DMF: 30 mg/mL (103.33 mM), Sonication is recommended.

溶液配制表

DMSO/DMF

	1mg	5mg	10mg	50mg
5 mM	0.6888 mL	3.4442 mL	6.8885 mL	34.4424 mL
10 mM	0.3444 mL	1.7221 mL	3.4442 mL	17.2212 mL
20 mM	0.1722 mL	0.8611 mL	1.7221 mL	8.6106 mL
50 mM	0.0689 mL	0.3444 mL	0.6888 mL	3.4442 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7221 mL