Name: Mudanpioside E
Brand: TargetMol
SKU: TN13046
Price: 1300 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,300

现货

5 mg

¥ 3,250

现货

10 mg

¥ 4,730

现货

25 mg

¥ 7,490

现货

50 mg

¥ 9,870

现货

生物活性

产品描述	Mudanpioside E is a paeoniflorin-type monoterpenoid glycoside naturally found in plants of the Paeoniaceae family. Mudanpioside E is an orally active antiallergenic agent that inhibits IgE-mediated β-hexosaminidase release (IC₅₀ = 40.34 μM). Mudanpioside E can reverse the inhibitory effect of Xiao Qing Long Tang extract, a formulation containing Paeonia lactiflora root, on passive cutaneous anaphylaxis in mice, making it suitable for research on allergic diseases.
靶点活性	β-hexosaminidase:40.34 μM
体外活性	方法：RBL-2H3细胞（IgE致敏）加入Mudanpioside E (10.0-100.0 μM) 预孵育30 min，然后加入DNP-BSA共同孵育1 h，检测β-己糖胺酶释放抑制率；CCK-8细胞检测活力。结果：Mudanpioside E 可显著抑制 IgE 介导的 β-己糖胺酶释放 (脱颗粒的标志物)，其 IC50 为 40.34 μM，且在浓度高达 100.0 μM 时无细胞毒性。[1]
体内活性	Mudanpioside E (0.55 g/kg-2.2 mg/kg;口服灌胃; 单次给药) 可剂量依赖性地抵消去白芍成分的小青龙汤提取物对小鼠被动皮肤过敏反应 (PCA) 的抑制作用。[2]

化学信息

分子量	526.49
分子式	C₂₄H₃₀O₁₃
CAS No.	172705-25-8
Smiles	C(OC(=O)C1=CC(OC)=C(O)C=C1)[C@@]23[C@@]4(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@]6(C)O[C@@]2(O[C@@](O)([C@@]3(C4)[H])C6)[H]

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Mudanpioside E